Receptor polymorphisms and non-classical immune stimuli in bacterial immune recognition

Receptor polymorphisms and non Receptor polymorphisms and non Receptor polymorphisms and non Receptor polymorphisms and non-classical immune classical immune classical immune classical immune stimuli in bacterial immune recognition stimuli in bacterial immune recognition stimuli in bacterial immune recognition stimuli in bacterial immune recognition Receptor polymorphisms and non Receptor polymorphisms and non Receptor polymorphisms and non Receptor polymorphisms and non-classical immune classical immune classical immune classical immune stimuli in bacter stimuli in bacter stimuli in bacter stimuli in bacterial immune recognition ial immune recognition ial immune recognition ial immune recognition me with this projekt, for the continous support and confidence in my work. Especially the enthusiastic and helpfull character of the supervision by Corinna Hermann had always granted the motivation throughout the time. The critical reading of the manuscript by her was of great help. I thank Prof. Dr. Albrecht Wendel for welcoming me into the group, for his support and his engagement in the " International Research Training Group IRTG 1331. " I am grateful for the excellent working facilities provided at the Chair of Biochemical Pharmacology and for the opportunities I had to attend conferences, courses and transfer projekts. I am indebted to the Deutsche Forschungsgesellschaft (DFG) for financial support. I thank all co-authors and collaborators for their valuable contributions to this work, concerning chemical analysis. ACKNOWLEDGEMENTS III Special appreciation is owed our technical right hands Leonardo Cobianchi for numerous LTA preparations and Margarete Kreuer-Ullmann for organizing the murine experiments, as well as all the indispensable blood donors both from the Uni Konstanz and from the IBD patients' collective. Sincere thanks I give to the whole team for the practical and mental support, for the bright working atmosphere and unforgettable times in-and outside the lab. Finally, I want to acknowledge the all-round support by my parents and the readiness of my wife Netti to ceaselessly taking great care of our sons. Major parts of this thesis are published or submitted for publication. stronger toll-like receptor 4-triggering than TNF-a possible explanation for the selective effects of heterozygous TLR4 polymorphism Asp(299)Gly on IL-10 release. Immunobiol 2008; in press. ► O. Dehus, G. Rogler and C. Hermann: LPS-inducible anti-inflammatory responses are not diminished in Crohn's disease patients with heterozygous Asp(299)Gly polymorphism. Submitted to IBD. ► O. Dehus, T. Hartung and C. Hermann: Endotoxin evaluation of eleven lipopolysaccharide by whole blood assay does not always correlate with Limulus Amebocyte Lysate assay. immunogenicity of …